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Selected publications

2026

  • The role of histone demethylase PHF2 as a tumour suppressor in hepatocellular carcinoma by regulating SRXN1Thng DKH, Hooi L, Yong WK, … Chow EK-H — Oncogenesis (15: 6)doiProteome

2025

  • Wnt target IQGAP3 promotes Wnt signaling via disrupting Axin1-CK1α interactionRahmat MB, Hussain A, Teh YX, … Ito Y — Oncogene (44: 3831–3849)doiInteractome
  • Multiple myeloma associated long non-coding RNA PLUM confers chemoresistance by enhancing PRC2 mediated UPR pathway activationDeka K, Carter J-M, Bahai A, … Li Y — Nature Communications (16: 8155)doiInteractome

2024

  • An isoform-resolution transcriptomic atlas of colorectal cancer from long-read single-cell sequencingLi Z, Zhang B, Chan JJ, … Tay Y — Cell Genomics (4: 100641)doiClinical
  • A PRMT4-ZNF326 axis mediates innate immune activation upon replication stressHoang PM, Torre D, Jaynes P, … Jeyasekharan AD — Science Advances (10: eadm9589)doiProteomePTM
  • ZBTB48 is a priming factor regulating B-cell-specific CIITA expressionRane G, Kuan VLS, Wang S, … Kappei D — Oncogene (43: 6236–6263)doiProteome

2023

  • ASCL1 characterizes adrenergic neuroblastoma via its pioneer function and cooperation with core regulatory circuit factorsWang L, Tan TK, Kim H, … Sanda T — Cell Reports (14: 8252)doiInteractome
  • LINC00116-encoded microprotein mitoregulin regulates fatty acid metabolism at the mitochondrial outer membraneZhang S, Guo Y, Fidelito G, … Ho L — iScience (26: 107558)doiInteractome
  • The effect of inhibition of receptor tyrosine kinase AXL on DNA damage response in ovarian cancerYeo XH, Sundararajan V, Wu Z, … Huang RY — Communications Biology (6: 660)doiInteractome

2022

  • A degradative to secretory autophagy switch mediates mitochondria clearance in the absence of the mATG8-conjugation machineryTan HWS, Lu G, Dong H, … Shen HM — Nature Communications (13: 3720)doiProteome
  • Multilayered control of splicing regulatory networks by DAP3 leads to widespread alternative splicing changes in cancerHan J, An O, Ren X, … Chen L — Nature Communications (13: 1793)doiInteractome
  • PLK1 inhibition selectively induces apoptosis in ARID1A deficient cells through uncoupling of oxygen consumption from ATP productionSrinivas US, Tay NSC, Jaynes P, … Jeyasekharan AD — Oncogene (41: 1986–2022)doiProteome
  • Global analysis of RNA-binding proteins identifies a positive feedback loop between LARP1 and MYC that promotes tumorigenesisDesi N, Tong QY, Teh V, … Tay Y — Cellular and Molecular Life Sciences (79: 147)doiInteractome
  • The H. pylori CagA oncoprotein induces DNA double strand breaks through Fanconi anemia pathway downregulation and replication fork collapseKolinjivadi AM, Sankar H, Choudhary R, … Ito Y — International Journal of Molecular Sciences (23: 1661)doiProteome

2021

  • Highly recurrent CBS epimutations in gastric cancer CpG island methylator phenotypes and inflammationPadmanabhan N, Kyon HK, Boot A, … Tan P — Genome Biology (22: 167)doiProteome
  • Covalent conjugation of extracellular vesicles with peptides and nanobodies for targeted therapeutic deliveryPham TC, Jayasinghe MK, Pham TT, … Le MTN — Journal of Extracellular Vesicles (10: e12057)doiInteractome
  • Long-read transcriptome sequencing reveals abundant promoter diversity in distinct molecular subtypes of gastric cancerHuang KK, Huang J, Wu JK, … Tan P — Genome Biology (22: 44)doiProteome