QPC · Publications

Publications.

Projects supported by QPC across basic, translational, and clinical research.

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Selected publications

2026

• Loss of STMP1 Perturbs Mitochondrial Cristae and Drives Cellular Inflammation and Heart FailureRuberto FP, Lee CJM, Ackers-Johnson M, Sridharan P, Khanchandani V, Wu LH, Goh LX, Luu TDA, Pakkiri LS, Bonne I, Lu TB, Buss DJ, Lovelace T, Subramanian V, Villanueva E, Hu Y, Vidyasekar P, Gurung R, Lee JM, Yong WK, Li Z, Kappei D, Ho L, Drum CL, Foo RSY — Circulation (Online ahead of print, 2026 Jun 10)doiProteome
• qChIP-MS reveals the local chromatin composition by label-free quantitative proteomicsYong WK, Zaal Anuar N, Sin ZW, Tan ESR, Rane G, Shao X, Goh CY, Khanchandani V, Kuan VLS, Ong PF, Jeitany M, Koeffler HP, Deng LW, Dreesen O, Sanda T, Kappei D — Nature Communications (Online ahead of print, 2026 May 26)doiProteomeInteractome

2025

• Wnt target IQGAP3 promotes Wnt signaling via disrupting Axin1-CK1α interactionRahmat MB, Hussain A, Teh YX, Dutta B, Pundrik S, Kappei D, Ito Y — Oncogene (44: 3831–3849)doiInteractome
• Multiple myeloma associated long non-coding RNA PLUM confers chemoresistance by enhancing PRC2 mediated UPR pathway activationDeka K, Carter J-M, Bahai A, Ang DA, Sim N, Chong HY, Lee GHB, Tan SM, Chng WJ, Kappei D, Li Y — Nature Communications (16: 8155)doiInteractome

2024

• An isoform-resolution transcriptomic atlas of colorectal cancer from long-read single-cell sequencingLi Z, Zhang B, Chan JJ, Tabatabaeian H, Tong QY, Chew XH, Fan X, Driguez P, Chan C, Cheong F, Wang S, Siew BE, Tan IJ-W, Lee K-Y, Lieske B, Cheong WK, Kappei D, Tan K-K, Gao X, Tay Y — Cell Genomics (4(9): 100641)doiClinical
• A PRMT4-ZNF326 axis mediates innate immune activation upon replication stressHoang PM, Torre D, Jaynes P, Ho J, Mohammed K, Alvstad E, Lam WY, Khanchandani V, Lee JM, Toh CMC, Lee RX, Anbuselvan A, Lee S, Sebra RP, Walsh MJ, Marazzi I, Kappei D, Guccione E, Jeyasekharan AD — Science Advances (10(23): eadm9589)doiProteomePTM
• ZBTB48 is a priming factor regulating B-cell-specific CIITA expressionRane G, Kuan VLS, Wang S, Mok MMH, Khanchandani V, Hansen J, Norvaisaite I, Zulkaflee N, Yong WK, Jahn A, Mukundan VT, Shi Y, Osato M, Li F, Kappei D — The EMBO Journal (43: 6236–6263)doiProteome

2023

• ASCL1 characterizes adrenergic neuroblastoma via its pioneer function and cooperation with core regulatory circuit factorsWang L, Tan TK, Kim H, Kappei D, Tan SH, Look AT, Sanda T — Cell Reports (42(12): 113541)doiInteractome
• LINC00116-encoded microprotein mitoregulin regulates fatty acid metabolism at the mitochondrial outer membraneZhang S, Guo Y, Fidelito G, Robinson DRL, Liang C, Lim R, Bichler Z, Guo R, Wu G, Xu H, Zhou QD, Singh BK, Yen PM, Kappei D, Stroud DA, Ho L — iScience (26: 107558)doiInteractome
• The effect of inhibition of receptor tyrosine kinase AXL on DNA damage response in ovarian cancerYeo XH, Sundararajan V, Wu Z, Phua ZJC, Ho YY, Peh KLE, Chiu Y-C, Tan TZ, Kappei D, Ho YS, Tan DSP, Tam WL, Huang RY — Communications Biology (6: 660)doiInteractome

2022

• A degradative to secretory autophagy switch mediates mitochondria clearance in the absence of the mATG8-conjugation machineryTan HWS, Lu G, Dong H, Cho Y-L, Natalia A, Wang L, Chan C, Kappei D, Taneja R, Ling S-C, Shao H, Tsai S-Y, Ding W-X, Shen H-M — Nature Communications (13: 3720)doiProteome
• Multilayered control of splicing regulatory networks by DAP3 leads to widespread alternative splicing changes in cancerHan J, An O, Ren X, Song Y, Tang SJ, Shen H, Ke X, Ng VHE, Tay DJT, Tan HQ, Kappei D, Yang H, Chen L — Nature Communications (13: 1793)doiInteractome
• PLK1 inhibition selectively induces apoptosis in ARID1A deficient cells through uncoupling of oxygen consumption from ATP productionSrinivas US, Tay NSC, Jaynes P, Anbuselvan A, Ramachandran GK, Wardyn JD, Hoppe MM, Hoang PM, Peng Y, Lim S, Lee MY, Peethala PC, An O, Shendre A, Tan BWQ, Jemimah S, Lakshmanan M, Hu L, Jakhar R, Sachaphibulkij K, Lim LHK, Pervaiz S, Crasta K, Yang H, Tan P, Liang C, Ho L, Khanchandani V, Kappei D, Yong WP, Tan DSP, Bordi M, Campello S, Tam WL, Frezza C, Jeyasekharan AD — Oncogene (41(13): 1986–2022)doiProteome
• Global analysis of RNA-binding proteins identifies a positive feedback loop between LARP1 and MYC that promotes tumorigenesisDesi N, Tong QY, Teh V, Chan JJ, Zhang B, Tabatabaeian H, Tan HQ, Kapeli K, Jin W, Lim CY, Kwok ZH, Tan HT, Wang S, Siew BE, Lee K-C, Chong C-S, Tan K-K, Yang H, Kappei D, Yeo GW, Chung MCM, Tay Y — Cellular and Molecular Life Sciences (79(3): 147)doiInteractome
• The H. pylori CagA Oncoprotein Induces DNA Double Strand Breaks through Fanconi Anemia Pathway Downregulation and Replication Fork CollapseKolinjivadi AM, Sankar H, Choudhary R, Tay LS, Tan TZ, Murata-Kamiya N, Voon DCC, Kappei D, Hatakeyama M, Krishnan V, Ito Y — International Journal of Molecular Sciences (23: 1661)doiProteome

2021

• Highly recurrent CBS epimutations in gastric cancer CpG island methylator phenotypes and inflammationPadmanabhan N, Huang KK, Boot A, Lim K, Srivastava S, Chen S, Wu Z, Lee H-O, Mukundan VT, Chan C, Chan YK, Ong X, Pitt JJ, Isa ZFA, Xing M, Lee MH, Tan ALK, Ho WT, Luftig MA, Kappei D, Kruger WD, Bian J, Ho YS, Teh M, Rozen SG, Tan P — Genome Biology (22: 167)doiProteome
• Covalent conjugation of extracellular vesicles with peptides and nanobodies for targeted therapeutic deliveryPham TC, Jayasinghe MK, Pham TT, Yang Y, Wei L, Usman WM, Chen H, Pirisinu M, Gong J, Kim S, Peng B, Wang W, Chan C, Ma V, Nguyen NTH, Kappei D, Nguyen X-H, Cho WC, Shi J, Le MTN — Journal of Extracellular Vesicles (10: e12057)doiInteractome
• Long-read transcriptome sequencing reveals abundant promoter diversity in distinct molecular subtypes of gastric cancerHuang KK, Huang J, Wu JKL, Lee M, Tay ST, Kumar V, Ramnarayanan K, Padmanabhan N, Xu C, Tan ALK, Chan C, Kappei D, Goke J, Tan P — Genome Biology (22: 44)doiProteome